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1 article(s) from Stegemann, Anne-Katrin

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

Susanne Huhmann,
Anne-Katrin Stegemann,
Kristin Folmert,
Damian Klemczak,
Johann Moschner,
Michelle Kube and
Beate Koksch

Beilstein J. Org. Chem. 2017, 13, 2869–2882, doi:10.3762/bjoc.13.279

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Graphical Abstract

Figure 1: (a) Structures of isoleucine (1), leucine (2), and their fluorinated analogues 5,5,5-trifluoroisole...

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Figure 2: Percentage of substrate remaining after incubation for 120 min (left) and 24 h (right) with α-chymo...

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Figure 3: Cleavage positions observed in the digestion of library peptides with α-chymotrypsin.

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Figure 4: Percentage of substrate remaining after incubation for 120 min (left) and 24 h (right) with pepsin ...

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Figure 5: Cleavage positions for digestion of the different peptides with pepsin.

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Figure 6: Percentage of substrate remaining after incubation for 120 min (left) and 24 h (right) with elastas...

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Figure 7: Cleavage positions for digestion of the different peptides with elastase.

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Figure 8: Percentage of substrate remaining after incubation for 120 min (left) and 24 h (right) with protein...

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Figure 9: Cleavage positions found with proteinase K.

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Figure 10: Dimension of stabilization or destabilization upon TfIle or HfLeu incorporation compared to the non...

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Published 22 Dec 2017

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